Basic NSAIDs are gaining interest because of their improved biological properties with the aim of improving the therapeutic index through prevention of gastrointestinal complications. Pyrazole and benzothiazoles are well established in literature as important biologically active heterocyclic compounds. A series of some novel 2-aminobenzothiazole derivatives were synthesized. These substituted 2-aminobenzothiazoles (Ia-f) has been reacted with acetyl acetone and different hydrazines to give various (3,5-dimethyl-1-substitutedphenyl-1H-pyrazole-4-yl)-(substituted benzothiazole-2-yl)-diazene (IIIa-r). The purity of the synthesized compounds was checked by TLC. All the synthesized compounds were characterized by IR, 1H NMR and mass spectral studies and screened for their anti-inflammatory activity by in-vitro method using analgin as a standard drug. Out of the eighteen test compounds, compounds IIIa, IIIb, IIIh, IIIn showed good anti-inflammatory activity.
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